Human cells dwell in salt water. Their well-being depends on the ability of the body to regulate the salinity of extracellular fluids. By controlling water intake and excretion, the osmoregulatory ...

Cells exposed to changes in extracellular osmolarity activate a conserved network of responses to maintain volume, ion balance and macromolecular function. Acute hypertonic stress drives water efflux, ...

This study explored whether the increased extracellular relative to intracellular fluid (ECF/ICF) ratio in obesity might reflect osmotic effects of elevated plasma solute concentrations. The present ...