Scientists have deciphered molecular-level details of the complex choreography by which intricate cellular proteins recognize and bind to DNA to start the DNA replication process. The research may ...
Genome duplication must occur before cell division, so that both progeny cells inherit a complete copy of the genetic material. DNA replication is initiated at particular chromosomal sites called ...
A clearer understanding of the origin recognition complex -- a protein complex that directs DNA replication -- through its crystal structure offers new insight into fundamental mechanisms of DNA ...
The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
The proteins responsible for the initiation of DNA replication are thought to be essentially unrelated in bacteria and archaea/eukaryotes. Here we show that RepA, the initiator from the Pseudomonas ...
Nuclear-encoded regulatory proteins control mitochondrial translation. A few, however, are encoded by the mitochondrial DNA (mtDNA) and are produced by the mitochondrial translation machinery.
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