Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...

α-Synuclein (α-Syn) is a presynaptic protein primarily associated with Parkinson’s disease and other neurodegenerative diseases. The cholesterol content in SV membranes regulates α-Syn binding to ...

The synaptotagmin protein family has been studied by neuroscientists for decades. However, most isoforms lack well-defined functions. Now, researchers have identified a crucial, presynaptic role for ...

α-synuclein (α-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphorylation of α-syn at ...

Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...

Amyloid plaques accumulate years before dementia, driven by release of the Aβ peptide from amyloid precursor protein (APP) in neurons. Now, new evidence points to synaptic vesicles as acidic hotspots ...