A pattern of changes in gene expression clustered in the cofilin pathway is consistently observed in mammary tumours and cells derived from them. The cofilin pathway has emerged as having a central ...

The two primary hallmarks of Alzheimer's disease are clumps of sticky amyloid-beta (Aβ) protein fragments known as amyloid plaques and neurofibrillary tangles of a protein called tau. Abnormal ...

A joint research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) and Queen Mary University of London (QMUL) has discovered the molecular mechanisms of how pathological ...

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin. The actin filament is a double-stranded helical structure ...

Scientists have identified a measurable indicator that could prove instrumental in the fight against HIV. The research focuses on cofilin, a key protein that regulates cells to mobilize and fight ...

Some cells, such as immune cells, are highly mobile—they constantly remodel their shape, migrate toward a wound that needs to be closed or chase down bacteria in the bloodstream. This mobility is ...

Muscle-specific protein cofilin-2 controls the length of actin filaments in muscle cells. Researchers have now revealed a new mechanism that is essential for the correct organization of related ...

Ischemia-reperfusion injury (IRI) leads to acute kidney injury (AKI), which poses serious threat to public health and society. Many clinical studies were conducted to evaluate several biomarkers in ...